Abnormal brain activity in lumbar disc herniation patients with chronic pain is associated with their clinical symptoms

Introduction Lumbar disc herniation, a chronic degenerative disease, is one of the major contributors to low back pain and disability. Although many studies have been conducted in past on brain function pain, most these did not classify (cLBP) patients according their etiology. The lack etiologic classification may lead inconsistencies between findings, correlation differences activation clinical symptoms with cLBP was less studied past. Methods In this study, 36 lumbar herniation (LDHCP) healthy controls (HCs) were included study activity abnormalities LDHCP. Visual analogue scale (VAS), oswestry disability index (ODI), self-rating anxiety (SAS), depression (SDS) used assess symptoms. Results results showed that LDHCP exhibited abnormally increased diminished regions compared HCs. Correlation analysis amplitude frequency fluctuations (ALFF) left middle frontal gyrus negatively correlated SAS VAS, while right superior temporal positively dorsolateral are VAS SAS, respectively. Conclusion decreased controls. Furthermore, some activated or emotional